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Janani, S. K.
- Study on Formulation Development and Shelf Life Indicating Stability of Artesunate Loaded Self-Nanoemulsifying Drug Delivery System
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Authors
Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, (Affiliated to JSS University of Higher Education and Research, Mysuru), Ootacamund, IN
1 Department of Pharmaceutics, JSS College of Pharmacy, (Affiliated to JSS University of Higher Education and Research, Mysuru), Ootacamund, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3228-3236Abstract
Solubility plays an important role in the formulation. When a drug is poorly soluble, their bioavailability will be affected. However, the solubility of the drug can be enhanced by using various methods like pharmaceutical approach, pharmacokinetic approach and biological approach. It can also be improved by formulating a lipid based drug delivery system. In the present study, nanoemulsion has been developed by using oil, surfactant and a co-surfactant in order to increase the solubility of poorly soluble BCS Class II and Class IV drugs. Nanoemulsions can be prepared by different techniques. In the current study, nanoemulsion has been formulated by using simple spontaneous emulsification approach. Artesunate was used as a choice of drug and capryol 90 was used as oil in the present study. Pseudo-ternary phase diagrams were used in order to determine the oil and Smix ratio. After the formulation, the product was subjected to various evaluation studies like droplet size, zeta potential, PDI and viscosity etc. Further, the in-vitro dissolution test was carried out for the formulated product, marketed formulation and the pure drug. And it was observed that the formulated product showed an improved drug release. In addition to these evaluation tests, accelerated stability studies according to the ICH guidelines were also carried in order to determine the shelf life as well as the effect of added ingredients on the stability of the product. The shelf life of the product was observed to be 2.38 years at room temperature.Keywords
Artesunate, Solubility, Nanoemulsion, Stability Studies, Shelf Life.
References
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- Formulation Development and In vitro Characterization of Solid Self Nano Emulsifying Drug Delivery System for Curcumin to Target Colon Adenocarcinoma
Abstract Views :376 |
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Authors
Chenmala Karthika
1,
R. Sureshkumar
1,
Dheepak Upadhyay
1,
S. K. Janani
1,
C. Vasanthi
1,
M. Raja
1,
Sai Surya Nikitha Upathyayula
1
Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), IN
1 Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3338-3346Abstract
Cancer is the abnormal growth of cells in any part of the body; where when we are considering the Indian scenario, colon cancer stand to be forth in men and third in woman with the respect to mortality and incidence rate. The different dosage forms are available, oral delivery is most prominent and economic option for cancer treatment. In this present era the cost of the parenteral dosage form is increasing day by day hence the use of the oral drug delivery is more prominent, economical and convenient option for the cancer treatment. Curcumin is a flavonoid used in our day to day life which is proven to have an anti-cancer activity. For providing a colon specific action curcumin spheroid were formulated containing curcumin loaded self-nano emulsifying drug delivery system (SNEDDS) were prepared and evaluated. DSC reports confirmed the purity of the curcumin to be 99.25%. From the Preformulation studies report the solubility of the curcumin was found to be at maximum in Capryol 90. After the preparation of spheroids its characterisation, in vitro studies were performed which revealed the maximum release of 88.91% at pH 6.8. From IC50 value was found to be 21.1μg/ml. Therefore, curcumin loaded or entrapped in SNEDDS were formulated to spheroids and can be useful for the treatment of colorectal cancer.Keywords
Colon Cancer, Pectin, SNEDDS, Curcumin, in vitro Studies, Spheroids.References
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